ASH News Daily - Sunday, December 11, 2011 - (Page B-22)

Page B–22 ® ASH NewS DAily Sunday, December 11, 2011 career-development awardS Scholar Awards: ASH Invests in the Future of Hematology In 2008, Dr. ing the laboratory of Ross Levine, the discovery of prognostic Bunting moved to MD, more than three years ago, he importance of TET2 mutaNew York City and has been working on the discovery tions in AML as well as the joined Weill Cornell and characterization of somatic ge- finding that mutations in Medical College as netic alterations as well as normal IDH1/2 impair the function a postdoctoral assopolymorphisms, which are impor- of TET family of enzymes ciate in the Departtant in the pathogenesis of myeloid in collaboration with the ment of Medicine/ disorders. In particular, he has de- labs of Craig Thompson, Hematology-Onveloped an interest in understand- MD, and Ari Melnick, MD. cology. Under the ing the genetic, prognostic, and bioDr. Abdel-Wahab’s ASH guidance and menlogic implications of mutations in Scholar Award supports torship of Ari Melepigenetic modifiers his research Karen L. Bunting, PhD nick, MD, and in in patients with myinto the role of eloid malignancies. ASXL1 in normal and close collaboration with Olivier ElHe has directly conmalignant hematopoiesis emento, PhD, her research centered Omar I. Abdel-Wahab, MD tributed to the disvia in vitro and in vivo on understanding the mechanisms Dr. Abdel-Wahab obtained his covery of the funcstudies. Dr. Abdel-Wa- of gene organization in normal and MD from Duke University. He then tional importance of hab is extremely honored malignant B cells. Dr. Bunting is completed his internal medicine mutations in several to receive an ASH Scholar using chromosome conformation residency at Massachusetts General of these genes that Award. He would like to capture experiments in combination Hospital followed by post-graduate we now believe to thank Stephen Nimer, with high-throughput sequencing training in hematology/oncology at be important for Martin Tallman, Ayalew to explore the way in which nuclear Memorial Sloan-Kettering Cancer prognosis, direction Tefferi, Iannis Aifantis, topology controls gene expression Center where he is currently an in- of therapy, and/or Craig Thompson, and Ari patterning in normal germinal censtructor in medicine and a member potential treatment Melnick for nurturing his ter B cells, how this is altered in DLof the leukemia service. Since join- targets. This includes Omar I. Abdel-Wahab, MD development as a physi- BCL, and whether the higher-order cian-scientist. Finally, Dr. organization of genes in DLBCL is a Abdel-Wahab is immensely grate- BCL6-mediated event. ful to his mentor Ross Levine for his continued encouragement and Brian T. Edelson, MD, MSc, PhD Dr. Edelson received his MD and guidance. PhD from the Washington University School of Medicine in St. Louis. Karen L. Bunting, PhD EHA-ASH TRANSLATIONAL RESEARCH Dr. Bunting graduated from the It was there that he completed his TRAINING IN HEMATOLOGY University of Adelaide, South Austra- residency training in clinical pathollia, with a Bachelor of Biomedical Sci- ogy, and now he is in his first year ence, followed by an Honors degree as an assistant professor in the DeADVANCE YOUR CAREER IN in 2001 from the Institute of Medical partment of Pathology and ImmuTRANSLATIONAL RESEARCH and Veterinary Science, where she nology. Dr. Edelson’s research has studied the pathogenesis of hemor- been focused on the development TRTH is an intensive training and mentoring and function of the inrhagic forms of dengue experience intended to advance the careers of young and gifted researchers and scientists. Established by the European Hematology nate immune system. virus. After working Association and the American Society of Hematology, TRTH is a highly selective His postdoctoral work as a research assistant international program focused on translational laboratory research with international in the laboratory of Kenwith Professor Richard experts in hematology. neth Murphy, MD, PhD, D’Andrea in the Leukaecharacterized transcripmia Biology Laboratory, Interested in refining your skills and taking your career to the next level? Apply for TRTH! tion factors important Child Health Research Participants work closely with faculty on topics such as biostatistics and biomarkers, for the development of Institute, Adelaide, on genetics and molecular biology, ethics, phase 1 clinical study design and professional macrophages and denmechanisms of GM-CSF networking. dritic cells (DCs), with receptor signaling, she particular emphasis on completed her PhD rethe development of DC search with Professor subsets, and their unique M. Frances Shannon at Brian T. Edelson, MD, functions during imThe John Curtin School For more information, go to www.ehaweb.org MSc, PhD mune responses. As part of Medical Research at or contact the EHA Executive Office at training@ehaweb.org. of this work, he used an The Australian National University in 2007. Her PhD thesis in vivo mouse model of intracellufocused on the role and function of lar bacterial infection with Listeria the NF-κB transcription factor, c-Rel, monocytogenes to understand how in inducible T-cell gene transcription. distinct DC subsets are important TRTH is being made possible by a generous unrestricted educational grant from the Wallace H. Coulter Foundation. Here, she developed a keen interest in during splenic infection. He is now chromatin organization and the mo- exploring the role of non-lymphoidlecular mechanisms of gene expression in cells of the immune system. »» SCHOLARS Page B-33 or over 25 years, ASH has supported more than 200 fellows and junior faculty in both basic and clinical/translational research by providing partial salary or other support during the critical period required for completion of training and achievement of status as an independent investigator. The following class of ASH Scholars began their awards on July 1, 2011. To find out more about the ASH Scholar Awards program, please visit www.hematology.org. Adv TRTH 1-4.indd 1 18-10-11 10:53 F http://www.hematology.org

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ASH News Daily - Sunday, December 11, 2011

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