ASH News Daily - Sunday, December 11, 2011 - (Page B-33)

Sunday, December 11, 2011 ASH NewS DAily cies. Working with Dr. Crispino, harboring MLL translocations. Dr. he characterized a mutated form Muntean’s research has led to the of the GATA1 transcription factor discovery of essential protein-profound in patients with tein interactions that are acute megakaryoblastic crucial for the establishleukemia. In 2007, Dr. ment and maintenance of Muntean began postdocMLL rearranged leuketoral work with Jay Hess, mias. This work helped MD, PhD, in the Departto define how oncogenic ment of Pathology at the fusion proteins bind to University of Michigan target loci in malignant in Ann Arbor. Under Dr. cells causing aberrant Hess, Dr. Muntean has gene transcription. His focused on the epigencurrent work focuses on etic modifications and fully characterizing and B:8.75 in biochemical interactions targeting these proteinT:7.5 in important for acute my- Andrew G. Muntean, protein interactions with S:6.75 in eloid leukemia (AML) PhD small molecules in the Page B–33 ® career-development awardS Scholars «« From Page B-22 tissue DCs in this infection model and attempting to understand the early cellular events that result in hepatic infection with Listeria. More recently, he has begun to study the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in DC development and the transcription factors induced by this hematopoietic growth factor. Hiyaa S. Ghosh, MSc, PhD Dr. Ghosh is currently working as a postdoctoral scientist in the Department of Immunology and MiJOB#: 10561 crobiology at Columbia University PROOF#: 1 CLIENT: Medical Center. AlexionConcept Jrnl Ad studies Her recent DESC: Disease Color: 4C have elucidated the role of the EAD: NT protein E2-2 TRAFFIC: CR in active maintenance of the matureOPERATOR: zv plasmacytoid dendritGALLEY#: 1 DATE: 10/19/11 - 7:53 PM ic cell fate. Prior to this, she worked CREATED: 7/22/11 - 5:38 PM on the anti-aging proteinBold FONTS: Trade Gothic LT Std SIRT1 durCondensed No. 20, Trade Gothic ing her doctoral dissertation, eluciLT Std Bold No. 2, Trade Gothic LT dating three Std Regular, Trade Gothic LT Std novel interaction partCondensed No. 18, Trade Gothic LT ners for SIRT1 and 18 Oblique potential Std Condensed No. their IMAGES: 10561C_journalAD_fn.tif, role in regulating NF-κB, the mTOR Alexion_KO.eps s i g n a l i n g COLORS: C=0 M=100 Y=75 K=5 NOTES: p a t h w a y , DOC PATH: Macintosh and cellular HD:Users:vazz:Desktop:10/19:ALX_ SLR_Q10561C_JA_D01:ALX_SLR_ stress regu- Q10561C_JA_D01.indd DOC SIZE: 10.75” X 13.25” lation. PRINT SCALE: 100% Defects in the myeloid differentiation pathway are linked to myeloid leukemia Hiyaa S. Ghosh, MSc, and myelo- PhD proliferative disorders. Dr. Ghosh is interested in the genetic regulation of the myeloid differentiation pathway of hematopoiesis – in particular, the regulation of cell fate decisions within the macrophage/DC progenitor differentiation pathway. With the support of the ASH Scholar Award, she will be investigating the role of E-protein/ETO transcriptional machinery in the monocyte/ DC/PDC development. Cosmos Communications 718.482.1800 hope that these discoveries will lead to novel therapies and improved treatment for AML patients. Dr. Muntean believes that defining the molecular underpinnings driving leukemia holds great promise for advancing specialized therapies. Dr. Muntean said, “It has been a great honor to receive the ASH Scholar Award in basic research as it recognizes my recent discoveries as important contributions to the field of leukemia research as well as provides me with the funding necessary for establishing a successful independent career.” »» SCHOLARS Page B-34 n xio 29 Ale 8 it oth Vis bo at Andrew G. Muntean, PhD Dr. Muntean received his BS in biology from Indiana University before earning his PhD in molecular genetics and cell biology from the University of Chicago in 2006 under the mentorship of John Crispino, PhD. He first became interested in the control of the hematopoietic system by lineage-specific transcription factors and also the genetic lesions driving hematopoietic malignan- 20658a C M Y K CATaHUSTROPHIC In atypical Hemolytic Uremic Syndrome (aHUS), chronic uncontrolled complement activation causes systemic thrombotic microangiopathy (TMA), which can result in sudden and progressive vital organ failure and premature death1-5 Chronic uncontrolled complement activation causes the continuous activation of platelets and endothelial cells, leading to systemic TMA.3,6 Systemic, complement-mediated TMA can lead to sudden, fatal complications and progressive failure of vital organs, including the kidneys, heart, and brain.1-4,7 aHUS is a devastating and life-threatening disease of chronic uncontrolled complement activation.1,2,5 10.19.11 133 1 ej 2 Q1 Q2 To learn more about aHUS, please visit booth 829 and www.aHUSsource.com References: 1. Loirat C, Noris M, Fremeaux-Bacchi V. Complement and the atypical hemolytic uremic syndrome in children. Pediatr Nephrol. 2008;23:1957-1972. 2. Noris M, Caprioli J, Bresin E, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010;5:1844-1859. 3. Fang CJ, Richards A, Liszewski MK, Kavanagh D, Atkinson JP. Advances in understanding of pathogenesis of aHUS and HELLP. Br J Haematol. 2008;143:336-348. 4. Sallée M, Daniel L, Piercecchi MD, et al. Myocardial infarction is a complication of factor H-associated atypical HUS. Nephrol Dial Transplant. 2010;25:2028-2032. 5. Loirat C, Garnier A, Sellier-Leclerc AL, Kwon T. Plasmatherapy in atypical hemolytic uremic syndrome. Semin Thromb Hemost. 2010;36:673-681. 6. Ståhl AL, Vaziri-Sani F, Heinen S, et al. Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation. Blood. 2008;111:53075315. 7. Neuhaus TJ, Calonder S, Leumann EP. Heterogeneity of atypical haemolytic uraemic syndromes. Arch Dis Child. 1997;76:518-521. Copyright © 2011, Alexion Pharmaceuticals, Inc. All rights reserved. SOL 1172A 

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ASH News Daily - Sunday, December 11, 2011

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